Not every person with a pathogenic variant will get cancer. However, people with a pathogenic variant do have an increased chance of developing cancer. Here, we present the known cancers associated with the pathogenic variant, and resources for risk management. This information is for educational purposes only and does not replace the advice of your healthcare provider. If you carry or suspect that you carry a pathogenic variant, please make an appointment with our hereditary cancer healthcare team to give you information on your risks based on your genetic testing results, family history, and other specific risk factors. We will discuss what is important to you and make recommendations for cancer screening.
ATM
CDKN2A
CHEK2
Cowden Syndrome (PTEN)
Hereditary Diffuse Gastric Cancer (CDH1)
Li-Fraumeni Syndrome (TP53)
Lynch Syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM)
NTHL1
PALB2
Peutz-Jegher syndrome (STK11)
RAD51C and RAD51D