While much has been accomplished in the clinical and research communities to understand the impact of BRCA mutations, there is more work to be done. Recent research has allowed us to develop a more in-depth understanding of the risks associated with these mutations; however, we at the Center are driven to continue to build on this research. There are different types of cancer related to BRCA mutations, and multiple types often appear within families. In families with multiple cases of breast or ovarian cancer, we understand that mutations in the BRCA1 or BRCA2 genes are responsible for a significant number of these cases.
We need to develop an understanding of the risk for other associated cancers such as pancreatic, prostate and melanoma in this patient population. Additionally, we understand these individuals have a high risk for cancer, but we do not yet know what the additional modifiers are that affect/impact this risk. We are working to develop a greater understanding of the risk associated with the development of these cancers as well as to find effective treatments to improve survival and quality of life.